Smaller posts - how many times I’ll promise myself those?
Sci-through
So, neurosymbolic stuff seems to be taking off. Or not - this time, at least.
After AlphaFold’s success, Deepmind is pursuing new ground with AlphaGenome - with a free non-commercial API! (Their tech report i-is here)
Uses CNNs + Transformers
In goes the DNA sequence (up to 1M base pairs, compared to <10k of OSS or ~200k for less precise nets)
Out goes the multimodal data on regulatory activity:
Bottom line? Now predicting how a single mutation may alter, say, cancer’s progression or a drug’s effifacy - is possible.
🆓 Other FOSS worth mentioning are:
💡
The thing is, those are only separate tasks. AlphaGenome does it all, and is the SOTA in the grand majority of tasks.
That’s called domination 😏 (or, having enough superstars, data and compute to realize your Matthew advantage.
AI AI AI Market Market Market
R-r-rovo (CLI Dev)
Yeah, yeah - Claude Code, Gemini CLI, Cursor, wow, such code.
Recently Atlassian had entered the game with a Claude Code wannabe-competitor called Rovo Dev (a short overview here). Even more TLDR:
Where it’s all headed?
I’d reckon there are several parts to the strategic puzzle (given you want to have your own opinion, rather than relying on the next big influencer I’m not one! I don’t influence!):
- If you’re confident in your ability to predict things - welcome to Polymarket, yeah. But also Quantified Intuitions! It has a-plenty of games that will impress and humble one - I, for one, was appalled at the number of birds dying to cats 🥲
Random facts
(The world has changed) And on a side note - capital seems to be shifting:
VC, hotels etc.
About Hilton’s hotel chain - it’s actually a bit scary to me that there are that many Hiltons:
While the company itself was founded by Conrad N. Hilton in 1919, the first hotel to bear the now iconic “Hilton” name wasn’t opened until six years later.
Now, a full century on, the business is still finding ways to grow its vast portfolio, which includes properties like Hilton Garden Inns and Hampton, its mid-range chain that has boomed to become the world’s largest lodging brand. Last year, Hilton opened more than two hotels on average every single day.
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