# On feeling rusty, DNA and random ML facts Smaller posts - how many times I’ll promise myself those? # Sci-through So, neurosymbolic stuff seems to be taking off. Or not - this time, at least. ![](https://cdn.hashnode.com/res/hashnode/image/upload/v1751111754543/25bb4629-5b23-4249-9abe-4e9d0c86c8a4.png align="center") After AlphaFold’s success, Deepmind is pursuing new ground with [AlphaGenome](https://deepmind.google/discover/blog/alphagenome-ai-for-better-understanding-the-genome/) - with a [free non-commercial API](https://www.alphagenomedocs.com/)! (Their tech report [i-is here](https://storage.googleapis.com/deepmind-media/papers/alphagenome.pdf)) * Uses CNNs + Transformers * In goes the DNA sequence (up to 1M base pairs, compared to <10k of OSS or ~200k for less precise nets) * Out goes the multimodal data on regulatory activity: ![overview of AlphaGenome](https://www.alphagenomedocs.com/_images/model_overview.png align="left") **Bottom line?** Now predicting how a single mutation may alter, say, cancer’s progression or a drug’s effifacy - is possible. 🆓 Other FOSS worth mentioning are: * [ChromBPNet](https://github.com/kundajelab/chrombpnet) (predicting chromatin accessibility) * [Splice AI](https://spliceailookup.broadinstitute.org/) (predicting [splicing](https://www.nature.com/scitable/topicpage/rna-splicing-introns-exons-and-spliceosome-12375/)) * [Borzoi](https://github.com/calico/borzoi) (predicting RNA-Seq from DNA, i.e. predicting gene expression) * [Boltz](https://github.com/jwohlwend/boltz) (affinity prediction with a generous [NVIDIA inference service](https://build.nvidia.com/mit/boltz2)): ![](https://cdn.hashnode.com/res/hashnode/image/upload/v1751113317223/9d7920fd-ad8d-42f0-b137-f569d9cea9ae.png align="center")
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The thing is, those are only separate tasks. AlphaGenome does it all, and is the SOTA in the grand majority of tasks.
![](https://cdn.hashnode.com/res/hashnode/image/upload/v1751115285999/50f30daf-71c2-47a5-8e53-319ac5a18de5.png align="center") That’s called *domination* 😏 (or, having enough superstars, data and compute to realize your [Matthew advantage](https://en.wikipedia.org/wiki/Matthew_effect). # AI AI AI Market Market Market ## R-r-rovo (CLI Dev) ![Introducing Rovo Dev CLI: AI-Powered Development i... - Atlassian Community](https://community.atlassian.com/forums/image/serverpage/image-id/394579i8C5F23614560CC2E?v=v2 align="center") Yeah, yeah - [Claude Code](https://www.anthropic.com/claude-code), [Gemini CLI](https://blog.google/technology/developers/introducing-gemini-cli-open-source-ai-agent/), Cursor, wow, such code. Recently Atlassian had entered the game with a Claude Code wannabe-competitor called [Rovo Dev](https://community.atlassian.com/forums/Rovo-for-Software-Teams-Beta/Introducing-Rovo-Dev-CLI-AI-Powered-Development-in-your-terminal/ba-p/3043623) (a short overview [here](https://garysvenson09.medium.com/claude-code-for-free-20m-daily-tokens-the-rovo-dev-gold-rush-and-how-to-max-it-out-d36725b5ff09)). Even more TLDR: * 20M tokens/day allowance, **but** 10.8k tokens system prompt each request + cached tokens are calculated in * Likely uses a [mix of Claude 3.5, 3.7 and 4](https://rovodevagents-beta.atlassian.net/wiki/external/Yzc2NzI4MTk3YTBhNDdiYjkzZDhhZTc3MjE0ZmE4Y2Q#Technical-information), but [Claude’s limits are different](https://support.anthropic.com/en/articles/11145838-using-claude-code-with-your-pro-or-max-plan#h_50f6dec29d) * From what I’ve seen, people are increasingly turning towards CC compared to [Cursor](https://www.producthunt.com/p/cursor/cursor-or-claude-code), [Gemini](https://www.reddit.com/r/ClaudeAI/comments/1ki531k/gemini_25_is_currently_the_better_standalone/) ([2](https://www.reddit.com/r/ClaudeAI/comments/1lkew5x/claude_code_vs_gemini_cli_initial_agentic/)), etc. Some are using [Claude as the brain and Gemini as the brawn](https://www.reddit.com/r/ChatGPTCoding/comments/1lm3fxq/gemini_cli_is_awesome_but_only_when_you_make/) (translating to English from *“Claude using Gemini as its bitch”*) * Someone had leaked their system prompt and made an [awesome write-up of the Z/80 technique](https://ghuntley.com/atlassian-rovo-source-code/): ![](https://ghuntley.com/content/images/2025/06/Editor-_-Mermaid-Chart-2025-06-14-054336.png align="center") ## Where it’s all headed? I’d reckon there are several parts to the strategic puzzle (given you want to have your own opinion, rather than relying on the next big influencer I’m not one! I don’t influence!): * [Market maps](https://github.com/joylarkin/Awesome-AI-Market-Maps) in the landscape of AI ![A periodic-like table showing multiple algorithms](https://news.mit.edu/sites/default/files/styles/news_article__image_gallery/public/images/202504/MIT_Periodic-Algorithm-01-PRESS_0.jpg?itok=kQ0_0ElK align="center") * [ML’s ‘periodic table’](https://news.mit.edu/2025/machine-learning-periodic-table-could-fuel-ai-discovery-0423) for realizing something from first principles * Some [awesome explainers](https://theaidigest.org/) and analyses, e.g. an [agent village](https://theaidigest.org/village), [2025-x forecast](https://theaidigest.org/ai2025-analysis-may), and [election disruption](https://theaidigest.org/elections) overview - the scary thing (for me) is that **it’s only getting better and at-scale**… ![](https://cdn.hashnode.com/res/hashnode/image/upload/v1751191377984/60cbb7ba-3dbc-4caa-840d-96ab98957816.png align="center") * If you’re confident in your ability to predict things - welcome to [Polymarket](https://polymarket.com/), yeah. But also [Quantified Intuitions](https://www.quantifiedintuitions.org/estimation-game)! It has a-plenty of games that will impress and humble one - I, for one, was appalled at the number of birds dying to cats 🥲 ## Random facts ![Galadriel The world is changed - The Lord of the Rings The Two Towers (2002) 4k (Open Matte) Scene - YouTube](https://i.ytimg.com/vi/TmS4zQArDvQ/hq720.jpg?sqp=-oaymwE7CK4FEIIDSFryq4qpAy0IARUAAAAAGAElAADIQj0AgKJD8AEB-AH-CYAC0AWKAgwIABABGBkgUSh_MA8=&rs=AOn4CLDDNKD4BTKBVrpkd6tzPknLtfVYnQ align="center") (The world has changed) And on a side note - capital seems to be **shifting**: ![](https://ci3.googleusercontent.com/meips/ADKq_NbQNfxDxktOh57eSLYuCTGiQx99vUR_fG3EgOgzKB5DTDWHRbJAaA3x-VCy9fa1lJRqSzfsQhLHBbdhhSeJqgdC30BYkGH5dp8yWekQPmJy_uOzma_bVNlVr9mduxir6iJ3CjAJ1JeA=s0-d-e1-ft#https://embed.filekitcdn.com/e/4ZFwDA8yeMmyhuZrTu8pkG/tKCgrNf5YsX4SsztktjnV5/email align="left") ## VC, hotels etc. About Hilton’s hotel chain - it’s actually a bit scary to me that there are **that many** Hiltons: ![Hilton hotels chart](https://sherwoodnews.imgix.net/2025-06-25-hilton.png?auto=compress%2Cformat&cs=srgb&fit=max&w=3840 align="center") > While the company itself was founded by Conrad N. Hilton in 1919, the first hotel to bear the now iconic “Hilton” name wasn’t opened until six years later. > > Now, a full century on, the business is still finding ways to grow its vast portfolio, which includes properties like Hilton Garden Inns and Hampton, its mid-range chain that has boomed to become the [**world’s largest** lodging bran](https://link.sherwood.news/click/40435287.4600/aHR0cHM6Ly93d3cuYmxvb21iZXJnLmNvbS9uZXdzL2ZlYXR1cmVzLzIwMjUtMDYtMTAvd2h5LWhhbXB0b24taW5uLWlzLXRoZS1ob3RlbC1icmFuZC10by1iZWF0P3NyZWY9cTNLU0ZwMzgmdXRtX3NvdXJjZT1jaGFydHImdXRtX21lZGl1bT1lbWFpbCZ1dG1fY2FtcGFpZ249Y2hhcnRyXzIwMjUwNjI1/65c2cd285d8daa7baa748e0bB04407847)d. Last year, Hilton opened **more than two** hotels on average every single day. --- Welcome to **Teleogenic**❣️ Other places I cross-post (not always) to: * [**Hashnode**](https://posts.teleogenic.com) * [**Medium**](https://baldr.medium.com/) * [**Telegram**](https://t.me/ohmyboi) * [**Twitter**](https://twitter.com/ZakharKogan) * [**LinkedIn**](https://www.linkedin.com/in/zakhar-kogan/)