# Remember remember # AI AI AI ![](https://cdn.hashnode.com/res/hashnode/image/upload/v1732086627008/730d51c3-7efe-4ec8-bb23-65201be17d46.png align="center") * [Learn about anything](https://learning.google.com/experiments/learn-about) by Google Experiments (use US VPN). Looks really useful: factual grounding, suggestions (including articles/videos), learning sections etc. * [Le Chat](https://mistral.ai/news/mistral-chat/) by Mistral had created waves yesterday, but I’m too slow to the party: still, it’s a free ChatGPT/ChatLLM/Claude alternative with web browsing, Flux pro image generation and even agents for different tasks. # Psychedelics ## [Combined Use of Psychedelics and Psychiatric Drugs](https://psychopharmacologyinstitute.com/section/examining-the-combined-use-of-psychedelics-and-psychiatric-drugs-2813-5750) ![Interactions between classic psychedelics and serotonergic antidepressants: Effects on the acute psychedelic subjective experience, well-being and depressive symptoms from a prospective survey study - Jessica Barbut Siva, Tommaso Barba, Hannes Kettner ...](https://journals.sagepub.com/cms/10.1177/02698811231224217/asset/images/large/10.1177_02698811231224217-fig2.jpeg align="left") * **SRIs potentially block** psychedelic subjective and therapeutic effects ([2a downregulation after SSRI use](https://www.sciencedirect.com/science/article/abs/pii/S0361923001006232) in effect?). The duh-searchers didn’t find any attenuation after [two weeks](https://doi.org/10.1002/cpt.2487) on escitalopram, which is **tiny dick energy study design** * **SRIs + MDMA** = attenuation after SRI adaptation, 5HT syndrome before it * **Bupropion** enhances MDMA effects * Don’t combine **lithium** with psychedelics, especially LSD - it’s a good way to [copslay a foam bath](https://psychedelichealth.co.uk/2021/08/13/mixing-psychedelics-with-lithium-poses-significant-risk-of-seizures/) * Combine **ibogaine** with anything at your own risk (especially [QT prolonging meds](https://www.nejm.org/doi/full/10.1056/NEJMc0804248)) ## [Psychedelic-Assisted Therapy in Clinical Practice](https://psychopharmacologyinstitute.com/section/psychedelic-assisted-therapy-in-clinical-practice-2813-5751) ![КОГДА ОТПУСТИТ, ПРО МЕНЯ ОСОБО НЕ ПИЗДИ И ПРО ТЕЛЕПОРТАЦИЮ ...](https://encrypted-tbn0.gstatic.com/images?q=tbn:ANd9GcRuZn4qiDO6m0vn4u0v_uzt2VQIXK5sqwmxlA&s align="center") * Needs a **structured approach**: preparation session, main session (2 therapists), integration sessions (more important than main session IMO) * **Clusterfuck trips** now *“challenging experiences”* and *“food for engagement and insight”*. A lot of insight from being a road sign for a couple of eternities! * **Benzos** as a backup (not 2a antagonists to engage in difficult trip portions) * Not for history of **psychotic episodes** and **severe mental disorders** running in family * So: * **Costly** mainly because of personnel involved + psychological risks * **Not scalable or generalizable** as a lot of peeps are screened out ## [Xenobots and anthrobots](https://www.perplexity.ai/page/third-state-beyond-life-and-de-i7XQHDBDRqSjAxIpOVBIQw) ![Anthrobots: The New Human Cell Robots Redefining Histology](https://i0.wp.com/laboratoryintern.com/wp-content/uploads/2023/12/image-2.jpg?resize=900%2C356&ssl=1 align="left") * Scientists had managed to create [tiny self-organizing robots from human cells](https://kimbellard.medium.com/from-xenobots-to-anthrobots-5b87b55c703e#bypass) * Skin cells formed **xenobots**, multicellular structures that can navigate surroundings * %[https://www.youtube.com/watch?v=0MS_18Sje7g] Lung cells formed **anthrobots**, capable of movement, self-repair and accepting donations repairing neighbor cells * Looks like that can be used for **garbage/mucus/infection management** as soon as those mechanisms are better researched and managed ## [Looks like HIV prophylaxis is so near](https://www.cnbc.com/2024/09/12/gilead-lenacapavir-cut-hiv-infections-by-96percent-in-trial.html) (not sure) ![HIV Capsid Lenacapavir Review Treatment & Prevention, PK, Mechanism, Resistance](https://www.natap.org/2022/images/011522/011522-5/0114223.gif align="left") * Gilead’s lenacapavir shows 96-100% efficiency in preventing HIV/AIDS in a couple of trials * It’s a twice-yearly injection, works as a capsid inhibitor * As usual: * “excluding individuals at risk from receptive vaginal sex” * “DESCOVY FOR PrEP must be prescribed only to individuals confirmed to be HIV negative immediately prior to initiation and at least every 3 months during use” * “Severe acute exacerbations of hepatitis B have been reported in individuals infected with hepatitis B virus (HBV) who discontinued products containing FTC and/or TDF and may occur with discontinuation of DESCOVY” * “DESCOVY FOR PrEP is contraindicated in individuals with unknown or positive HIV status” * “Discontinue DESCOVY in individuals who develop clinically significant decreases in renal function or evidence of Fanconi syndrome” * But hey, it’s an honest miracle drug!! # Reading ## [Meaning after religion](https://greatergood.berkeley.edu/article/item/why_people_quit_religion_and_how_they_find_meaning_again) ### Why people leave religion? ![Ultra-Orthodox Jews Must Choose Between Obedience to Their Rabbis – or to Their Smartphone - Israel News - Haaretz.com](https://img.haarets.co.il/bs/0000017f-db0a-d856-a37f-ffca78520000/e8/e4/302504782bd3ec2cf53cd0d119f8/1018316866.jpg?precrop=1368,1367,x410,y0 align="left") * **Cultural stagnation**: you’d love to use latest smartphones and learn and create, but are forced to use an old phone… Or you don’t share the religion’s elden views on racism/LGBTQ/anything * **Abuse**: either spiritual (don’t leave or else…) or physical (they say you’re grown up when the sermon stops winking at you?) * **Suffering**: some schools of religion view existence as suffering, or appropriate the need to suffer (aye to self-whipping) to achieve salvation * **Labelling**: some are finding the religious label/stigma uncomfortable in current times. A [recent poll indicated](https://thestateoftheology.com/) that more than 40% of self-identified evangelicals do not believe in Jesus. But Jesus [is not that bad](https://www.youtube.com/watch?v=j8ZF_R_j0OY)! ### Leaving religion ![Belief in God and Psychological Distress: Is It the Belief or Certainty of the Belief?](https://pub.mdpi-res.com/religions/religions-12-00757/article_deploy/html/images/religions-12-00757-g001.png?1632394293 align="left") * Starts with deconstruction of religious belief framework, which can be **extremely** destabilizing. Akin to the [Dark Night of the Soul](https://en.wikipedia.org/wiki/Dark_Night_of_the_Soul) and [The Dark Night](https://www.shinzen.org/the-dark-night/) in buddhism, yeah. * Then goes either religious **reconstruction** (beliefs had changed) or **deidentification** (outside of religion) * A weird phenomenon called [religious residue](https://psycnet.apa.org/record/2020-17410-001) arises: people continue to be semi-consciously influenced by the religious tenets in life/money/relationships ### After… ![Freedom from Religion in 30 Days — Freedom From Religion Foundation](https://ffrf.org/wp-content/uploads/2024/04/freedomfromreligionin30days-scaled-1.jpg align="left") * A lot are reporting freedom, often coupled with anxiety (too much [freedom of choice](https://en.wikipedia.org/wiki/The_Paradox_of_Choice) is very stressful, isn’t it?) * The hardest questions (Who am I? What is good and wrong? What will happen to me?) are to be answered again, and it’s not an easy task considering the **answers were given and implanted** before * Relishing on some of religion’s values is great, and in the end it’s often a **rich assemblage of who someone is, who someone isn’t, his/her values intertwined with residual values** etc. --- Welcome to **Teleogenic**❣️ Other places I cross-post (not always) to: * [**Hashnode**](https://posts.teleogenic.com) * [**Medium**](https://baldr.medium.com/) * [**Telegram**](https://t.me/ohmyboi) * [**Twitter**](https://twitter.com/ZakharKogan) * [**LinkedIn**](https://www.linkedin.com/in/zakhar-kogan/)