# Going off the schedule ![](https://cdn.hashnode.com/res/hashnode/image/upload/v1729019520914/effb03bc-0af5-437e-bdda-c40026d9d1e0.png align="center") # Business ## [An article about Avra](https://thegeneralist.substack.com/p/avra) An elite accelerator for the world’s best startups and founders. Yeah, yeah... Can you feel that startups are becoming an industry in themselves, with ‘value’ and ‘traction’ being the prime examples of [Goodhart’s law](https://en.wikipedia.org/wiki/Goodhart%27s_law) - once people start valuing **something**\*,\* it’s usually great (wisdom of the crowds), but once everyone is jerking and showing off that same **something** (when everyone is raving about a stock, sell) - you know it’s slowly going to craps. ![](https://substackcdn.com/image/fetch/w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fbb80e284-4a95-42ce-8e90-f584216d4e45_4725x3675.jpeg align="center") ![](https://substackcdn.com/image/fetch/w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F55abbc5c-cebe-48a4-9b69-214370a1c7db_4725x2473.jpeg align="center") ![](https://substackcdn.com/image/fetch/w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fa3747d55-7f15-475b-a627-2f64bf2fcd3d_4725x3645.jpeg align="center") ## [CB Insights’ insights](https://www.linkedin.com/posts/norbertgehrke_cbinsights-game-changers-2025-activity-7245283716262993920-L5NR/). Such wow, much deep tech Without further atalk: 1. AI weather prediction, e.g. [DeepMind’s NeuralGCM](https://www.technologyreview.com/2024/07/22/1095184/a-new-weather-prediction-model-from-google-combines-ai-with-traditional-physics/) 2. Ultra-deep drilling 3. AI agent marketplaces; and hey [look at this](https://x.com/AISafetyMemes/status/1846220545542529329)! 4. [Advanced nuclear propulsion](https://www.nasa.gov/tdm/space-nuclear-propulsion/) 5. Biocomputing. Turns out it’s [not just brain organoids](https://en.wikipedia.org/wiki/Biological_computing), but a whole (micro)-world of stuff! 6. Brain manipulation tech 7. Quantum-optimized portfolios 8. Cellular & epigenetic reprogramming 9. GPS-less navigation systems. Middle East, [we’re looking at you](https://www.timesofisrael.com/gps-jamming-amid-wars-playing-havoc-with-airline-navigation-report/). ## [EVs in Norway](https://sherwood.news/tech/norways-ev-market-keeps-charging-ahead/) Just look at this beauty of a chart: ![Norway EVs](https://sherwoodnews.imgix.net/ev-sales-norway.png?auto=compress%2Cformat&cs=srgb&fit=max&w=3840 align="left") # Health ## [10k in a pill](https://nat.au.dk/en/about-the-faculty/news/show/artikel/new-molecule-can-mimic-the-effects-of-fasting-and-exercise) Guys from Aarhus University in Denmark (led by Dr Thomas Poulsen) had made a simple yet quite ingenious ‘exercise in a pill’: ![Figure 1](https://pubs.acs.org/cms/10.1021/acs.jafc.4c04849/asset/images/medium/jf4c04849_0009.gif align="center") 1. A precursor to lactate and beta-hydroxybutyrate which are elevated after exercise 2. It’s orally available, easy to synthesize (lactate and BHB bonded) 3. Novo Nordisk (the guys behind Ozempic epidemic) had already funded this research 4. (2) and (3) lead me to believe it will enter the market quite soon, as [Mmimetika Biosciences](https://mmimetika.com/) or under the NNordisk brand.. ## [Diet and ASD](https://www.reddit.com/r/ScientificNutrition/s/iiBeurfyfn) [![Dietary nutrients that potentially mitigate autism spectrum disorder and dietary recommendations for children and pregnant women - Li - 2024 - Food Frontiers - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/27b23122-05e3-49c5-991e-02db7e3b31e5/fft2380-fig-0003-m.jpg align="center")](https://onlinelibrary.wiley.com/doi/full/10.1002/fft2.380) TL;DR: * Ketogenic diet improved GI symptoms. Yet let’s [not forget its potential long-term woes](https://www.perplexity.ai/search/ketogenic-diet-long-term-dange-_dia6DTbQLiFWEubKrw6ow) * Gluten and Casein Free diet improved behavioral, cognitive, and GI symptoms * Omega-3 supplementation improved Cognitive and behavioral symptoms * Sulforaphane [may also be beneficial](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527484/) So it’s as usual: eat diverse foods, minimize gluten and casein, a sprinkle of polyphenols on top - et voila, you’re awesome! ## [Coffee and gut](https://www.reddit.com/r/ScientificNutrition/s/QTaTAFPvQL) ![The Gut Microbiome and its Effects on Human Health | Norgen Biotek Corp.](https://norgenbiotek.com/sites/default/files/images/blog/210604/gut-microbial-balance-figure-min.jpg align="left") * <4 cups → ⬆️Firmicutes ⬇️Bacteroidetes * Fun thing, higher F/B ratio is [associated with obesity](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285218/)… ## [Inulin and migraines](https://www.reddit.com/r/ScientificNutrition/s/4Ib8DnCxGG) ![](https://ars.els-cdn.com/content/image/1-s2.0-S1756464624004249-ga1_lrg.jpg align="left") * Inulin **decreased depression, stress and anxiety** scores, as well as migraine clinical score * **Didn’t change the QoL** (quality of life) score, though… ## [Akkermansia vs Olanzapine](https://psychopharmacologyinstitute.com/section/olanzapine-induced-weight-gain-can-akkermansia-muciniphila-help-2830-5757) ![A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion: Cell Metabolism](https://www.cell.com/cms/10.1016/j.cmet.2021.05.004/asset/201df879-0ff9-4753-a042-c89d15d7817b/main.assets/gr1_lrg.jpg align="left") Among [other virtues in weight management](https://www.perplexity.ai/search/akkermansia-and-obesity-83CrvQcDQXqqWjvErbDtBQ), (one being GLP-1 agonism, hehehe), Akkermansia muciniphilia will obviously help some for Olanzapine takers. [Ways to increase AM abundance](https://www.perplexity.ai/search/what-s-the-best-way-to-increas-baT61aYLQuqr4R8Ab9KlmQ) are as usual: * Polyphenols * Inulin, FOS, GOS * Rhubarb and soy! * Regular exercise * Avoiding saturated fats, sugars, and excessive protein * Resistant/potato starch Soo, just the usual “lead a healthy lifestyle, be happy and ye shall continue to do so”. If not, wait for the ‘10k in a pill’… --- Welcome to **Teleogenic**❣️ Other places I cross-post (not always) to: * [**Hashnode**](https://posts.teleogenic.com) * [**Medium**](https://baldr.medium.com/) * [**Telegram**](https://t.me/ohmyboi) * [**Twitter**](https://twitter.com/ZakharKogan) * [**LinkedIn**](https://www.linkedin.com/in/zakhar-kogan/)